个人简介

彭仁义，男，博士，讲师，硕士生导师

主要研究方向

糖尿病药理、药理药效机制探究；环境有害因子对健康的影响；斑马鱼资源利用与推广；

（本课题组主要招收药学方向硕士研究生）

发表论文

[1] New Progress in Zebrafish Liver Tumor Models: Techniques and Applications in Hepatocellular Carcinoma Research. International journal of molecular science., 260, (2025)26780, 3/3 (通讯)

[2] Mitochondrial homeostatic imbalance-mediated developmental toxicity to H2S in embryonic zebrafish. Environmental Pollution. 367(2025)125588, 11/11(通讯)

[3] Hydrogen sulffde mitigates mitochondrial dysfunction and cellular senescence in diabetic patients: Potential therapeutic applications. Biochemical Pharmacology. 230(2024)116556, 6/6 (通讯).

[4] SNP alleviates mitochondrial homeostasis dysregulation-mediated developmental toxicity in diabetic zebrafish larvae. Biomedicine & Pharmacotherapy. 2024,177:117117,10/11 (通讯).

[5] Immunotoxicity of microplastics in fish. Fish and Shellfish Immunology. 2024,150:109619,6/6 (通讯).

[6] Research Progress on Micro (Nano)Plastics Exposure-Induced miRNA-Mediated Biotoxicity. Toxics, 2024,12,475,5/5 (通讯).

[7] Research Progress on Micro(nano)plastic-Induced Programmed Cell Death Associated with Disease Risks. Toxics，2024,12,493, 8/8 (通讯).

[8] Understanding the links between micro/nanoplastics-induced gut microbes dysbiosis and potential diseases in fish: A review. Environmental Pollution. 2024,352:124103,7/7 (通讯).

[9] A systematic review of microplastics emissions in kitchens: Understanding the links with diseases in daily life. Environment International. 2024,118:108740,7/7 (通讯).

[10] Understanding the mechanistic roles of microplastics combined with heavy metals in regulating ferroptosis: Adding new paradigms regarding the links with diseases. Environmental Research.2024,242:117732,5/5 (通讯).

[11] Research Progress of Zebrafish Model in Aquatic Ecotoxicology.Water,2023, 15:1735, 5/5 (通讯).

[12] Factors Affecting the Adsorption of Heavy Metals by Microplastics and Their Toxic Effects on Fish. Toxics.2023,11-490,5/5 (通讯).

[13] Current updates of macrophage-loaded nanodrug delivery systems for the treatment of wound healing. Journal of Drug Delivery Science and Technology. 2023,86:104733,4/5 (通讯).

[14] Sodium nitroprusside alleviates nanoplastics-induced developmental toxicity by suppressing apoptosis, ferroptosis and inflammation. Journal of Environmental Management. 2023,118702,9/9 (通讯).

[15] New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics. Frontiers in Endocrinology. 2023,1230618,7/8(通讯).

[16] Research Progress on the Construction and Application of a Diabetic Zebrafish Model. International journal of molecular science. 2023, 24, 5195,5/5(通讯).

[17] Hydrogen sulfide-induced oxidative stress in embryo-larval stages of zebrafish leads to mitochondria-mediated apoptosis. Ecotoxicology and Environmental Safety. 2022,239:113666,9/9 (通讯).

[18] Advances in FGFs for diabetes care applications. Life sciences. 2022,310: 121015,8/9 (通讯).

[19] Toxic effects of cadmium on fish. Toxics. 2022,10:622,6/6(通讯).

[20] Recent Advances in Nano-Formulations for Skin Wound Repair Applications. Drug Design, Development and Therapy. 2022,16: 2707–2728,6/6 (通讯).

[21] LncRNAs regulate ferroptosis to affect the development of diabetes and its complications. Frontiers in Physiology. 2022,13:993904,7/7 (通讯).

[22] High glucose-induced ROS-accumulation in zebrafish larvae leads to mitochondria-mediated apoptosis. Apoptosis. 2022,27:509-520,7/7 (通讯).

[23] Crosstalk between Ca2+ and Other Regulators Assists Plants in Responding to Abiotic Stress. Plants-Basel. 2022, 11, 1351,4/4 (通讯).

[24] Nitric Oxide Alleviates Submergence‑Induced Maize Seedling Root Tip Cell Death. Journal of Plant Growth Regulation. 2022,42: 1212-1221,8/8 (通讯).

[25] Hydrogen Sulfide Enhances Plant Tolerance to Waterlogging Stress. Plants-Basel. 2021, 10:1928,5/5 (通讯).

[26] Recent Advances in ROS-Sensitive Nano-Formulations for Atherosclerosis Applications. Pharmaceutics. 2021, 13, 1452，2/7 (共一).

[27] Macrophage-Based Therapies for Atherosclerosis Management. Journal of Immunology Research, 2020, 2020: 1-11,2/7 (一作).

[28] Sustained-Release of Pdgf from Plga Microsphere Embedded Thermo-Sensitive Hydrogel Promoting Wound Healing by Inhibiting Autophagy. Journal of Drug Delivery Science and Technology, 55 (2020)，9/11 (通讯).

[29] Advances in refunctionalization of erythrocyte-based nanomedicine for enhancing cancer-targeted drug delivery. Theranostics. 2019, 9(23): 6885-6900,5/7 (参与).

[30] Hydrogen sulfide enhances nitric oxide induced tolerance of hypoxia in maize (Zea mays L.), Plant Cell Reports, 2016, 35: 2325-2340 (一作).

科研课题

[1] 斑马鱼疾病模型构建、病理机制研究、毒理学检测及市场开发的应用与推广，横向项目. 经费201万，2023/08 -- 2029/08，主持人；

[2]线粒体损伤与炎症感染关系的研究，横向项目，经费9万，2023/04 -- 2026/09，主持人；

[3]白菜花粉响应低温胁迫lncRNA-BrCBF4-COR基因调控通路研究，国家自然科学基金委员会面上项目，经费58万2020/01-2023/12，参与；

[4] H2S参与调控拟南芥水涝低氧信号感知N-end rule pathway的研究，浙江省自然科学基金青年项目，经费9万元，2020/01-2022/12， LQ20C020003，主持人；

[5] 新型气体信号分子硫化氢（H2S）增强植物耐受水涝低氧胁迫机制的研究，国家自然科学基面上项目，经费62万元，2017/01-2020/12，参加；

[6] 一氧化氮（NO）提升水涝灾害后玉米幼苗成活率的研究，温州市科技局项目，经费3 万元，2017.7-2020.10,主持人。

专利

[1]一种II型糖尿病斑马鱼模型的构建方法及应用,2023年授权发明专利, ZL202110197959.9，1/8

[2]一种斑马鱼养殖用过滤装置, 2021年授权实用新型专利,ZL202121396000.X，1/6

[3]一种斑马鱼养殖用定时投食装置, 2021年授权实用新型专利,ZL202121395774.0，1/6

[4]一种斑马鱼养殖用多功能观察系统, 2021年授权实用新型专利,ZL202121396032.X，1/6

[5]一种肥胖性II型糖尿病斑马鱼模型的构建方法及应用,2022年授权发明专利, ZL202110667786.2，2/6

[6]一种斑马鱼养殖用供水装置, 2021年授权实用新型专利, ZL202121395735.0，2/6

[7]一种用于斑马鱼养殖观察的养殖的净化装置,2022年授权实用新型专利, ZL202121397437.5，2/6

[8]一种便携式医学检验箱,2019年授权实用新型专利,ZL201821600237.3，2/2

[9]王磊;孙达;金立波;彭仁义;李瑶琦;一种构建糖尿病型斑马鱼模型的方法, 2022年授权发明专利,ZL202110297218.8，4/5

[10]一种斑马鱼有氧运动实验装置,2022年授权实用新型专利,ZL202122881754.0，5/5

联系电话：15957716937（微信同号）

电子邮箱：20170032@wzu.edu.cn